CLEVELAND – Midwest health care startups reported $564 million in total

investments through the first three quarters of 2006, a 36 percent increase over 2005 – outpacing national industry growth. Michigan was ranked seventh among 12 states surveyed.

Minnesota, the Midwest?s traditional leader in health care ventures, led all states with 18 startups attracting $181.8 million in investments so far this year. Three Minnesota companies posted the quarter?s largest Midwest financing rounds: Enteromedics, which raised $45 million, Cardiovascular

Systems, $25 million, and Anulex, $20 million.

Following Minnesota was Illinois with $101.6 million in six companies (though Illinois companies reported no new investment this past quarter), and

Ohio with $67.8 million across 19 companies.

The report aggregates venture investment in 10 Midwest states and Western Pennsylvania. Following the leaders are:

Kentucky ($51.4 million),

Western Pennsylvania ($46.4 million),

Missouri ($39.2 million),

Michigan ($38.9 million).

Indiana ($25.6 million)

Wisconsin ($11.5 million).

States with no reported financings included Iowa, Kansas, and West

Virginia.

In terms of Midwest regions, Minneapolis-St. Paul and Chicago led the region, followed by Cleveland and Pittsburgh.

?This quarter saw a significant number of large and small financings across the Midwest, increasing the number of existing, equity-financed companies throughout the geography,? said Baiju R. Shah,

President of BioEnterprise.

By sector, the equity funding was allocated as follows:

Biopharmaceutical companies: $254 million (45 percent) in 43 companies

Medical device companies: $225 million (40 percent) in 45 companies

Health care software and service companies: $85 million (15 percent) in 28 companies.

?Several Midwest companies completed successful public offerings including QuatRx (Michigan) and Cleveland BioLabs (Ohio), and several enjoyed successful strategic exits such as MinuteClinic (Minnesota, acquired by CVS) and Suros Surgical (Indiana, acquired by Hologic),? said Shah.

?In addition to equity financing, a number of Midwest companies are the recipients of significant State funds from programs designed to grow regional life science companies,? Shah added.

?For example, Michigan?s $2 billion 21st Century Jobs Fund and Ohio?s $1.6 billion Third Frontier Program have each awarded more than $30 million in 2006 to support bioscience start-ups and commercialization; the breadth and magnitude of these Midwest initiatives has not yet been recognized nationally where attention continues to focus on similar coastal programs that are still at

earlier stages of development or just discussion,? he said.

?With all of the deal activity across the spectrum of financing, it is no wonder that the Midwest health care community is experiencing increased interest from coastal investors and investment banks.?

Sources: Compiled by BioEnterprise team from Venture Wire, Private Equity Week, Wall Street Journal, Venture Source, SEC Filings, company press releases, and www.biospace.com.